There is a filter order that works for almost every segment, and following it means you always know which change caused which result.
- Geography. Where can you actually sell and support, and in which language will you write. This is a business constraint, so set it first and leave it alone.
- Industry. One or two standardized industries that contain your buyers.
- Company size. The narrowest band range where one message stays true.
- Seniority. The level with budget authority at that size.
- Title. Only if the function matters beyond the seniority band. Keep entries short and comma-separated.
- Keyword. Only if the industry is too coarse for your niche.
- Exclusions. Last, after you have read the preview and seen which titles keep turning up wrongly.
Read the count after every step and scroll the preview after steps 4 and 7. When it looks right, save it as a list with a name that describes the filters, so you can reproduce and defend it later.
The reason for this order is that each step constrains the next. Setting a title before you have set seniority and size makes it impossible to tell whether a small count is caused by the title or by everything else. Everything up to this point is free, so the discipline costs only attention.